A systems proteolipidomic approach identifies novel circulatory biomarkers for idiopathic dilated cardiomyopathy
Year: 2025
Type: article
Study design: Observational Study
Abstract: First study of global proteolipidomic changes in dilated cardiomyopathy (DCM). A machine-learning-guided biomarker pipeline identified 39 lipids and 10 proteins distinguishing DCM. We propose that PE (14:0/22:4), phosphatidic acid (PA) (18:1/20:1), and tetranectin (CLEC3B) may link oxidative stress, apoptosis, and ECM remodeling in DCM. A panel combining the top 8 lipid markers along with β2micoglobulin (B2M) and CLEC3B achieved an area under the curve (AUC) of 0.99, outperforming NT-proBNP and offering superior diagnostic accuracy.
Authors: Shubham Saha, Praveen Singh, Abhi Dutta, Anurag Raj, Mamta Rathore, Deepika Jindal, Hiteshi Vaidya, Santoshi Kumari, Prakash Chand Negi, Shantanu Sengupta, Sandeep Seth, Trayambak Basak
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4416999002