Work

The role of orosomucoid in glucose and lipid metabolism and metabolic diseases

Year: 2025

Type: article

Abstract: Dysregulation of glucose and lipid metabolism is closely linked to metabolic diseases such as obesity, diabetes, and diabetic nephropathy, posing serious threats to human health. Orosomucoid (ORM), an acute-phase protein, exhibits diverse biological functions such as immunomodulation, drug transport, and barrier maintenance. Accumulating evidence has recently revealed ORM's critical regulatory role in metabolic processes. Studies indicate that ORM modulates glucose and lipid metabolism through multiple mechanisms, including regulating food intake, attenuating adipose tissue inflammation and fibrosis, inhibiting adipocyte differentiation and hepatic steatosis, and promoting glycogen synthesis. This review systematically examines the regulatory mechanisms of ORM expression under inflammatory and metabolic stress conditions, the effects of ORM on glucose and lipid homeostasis, and its clinical associations with metabolic diseases. These insights could inform innovative strategies for preventing and treating metabolic diseases.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00304.2023

Authors: Xueli Zhang, Dongsheng Shang, Xia Deng, Zhaoxiang Wang, Guoyue Yuan

Institutions: Jiangsu University, Affiliated Hospital of Jiangsu University

Language: English

Topic: Adipokines, Inflammation, and Metabolic Diseases

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Natural Science Foundation of China, Natural Science Foundation of Jiangsu Province