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Targeting platelet-mediated CAP-1 upregulation in colorectal cancer: Mechanisms and small-molecule inhibitor development

Year: 2025

Type: article

Abstract: = 2.57 µM), effectively inhibited tumor metastasis in vivo, and showed no significant toxicity. These findings uncover a novel role for CAP-1 in mediating platelet-cancer cell interactions and suggest that CAP-1 inhibition represents a promising therapeutic strategy for metastatic colorectal cancer.

Source: Pharmacological Research

DOI: 10.1016/j.phrs.2025.108053

Authors: Jing Wang, Chenyu Lin, Pengbo Zhang, Xixi Huang, Wei Zhou, Mufan Wu, Jiaming Wang, Fenyong Sun, Bingdi Chen

Institutions: Tongji University, Shanghai East Hospital, Shanghai Tenth People's Hospital

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,130

Funders: Shanghai Municipal Health Commission, National Natural Science Foundation of China, Shanghai Municipal Health and Family Planning Commission, Shanghai Municipal People's Government

Awards: O-GlcNAc修饰YAP介导PAICS转录本的m6A甲基化促进肝母细胞瘤增殖及检验标志物开发研究, G7374314784, G8661519695

OpenAlex ID: W4416999593

FWCI:

Cites: 35

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