EROS protein: Decoding its pivotal role in redox homeostasis and disease pathogenesis
Year: 2025
Type: article
Abstract: The Essential for Reactive Oxygen Species (EROS) protein, a critical molecular chaperone for NADPH oxidase 2 (NOX2/gp91 phox ), has emerged as a central regulator of redox signaling and immune defense. Recent structural and functional studies reveal that EROS orchestrates NOX2 maturation, prevents spontaneous activation, and regulates reactive oxygen species (ROS) production. Dysfunction of EROS is implicated in chronic granulomatous disease (CGD), cancers and vascular pathologies. This review integrates structural insights into EROS-NOX2 interactions, discusses its dual roles in maintaining redox equilibrium and triggering oxidative stress, and explores therapeutic strategies targeting EROS-dependent pathways.
Source: Advances in Redox Research
Authors: Shiyu Liang, Youli Zhou, Wenfeng Ren, Yang Xu, Ming Tang, Yuxi Su, Li Li, Mei Gao
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,590
Awards: G4659526791, G8344883392
OpenAlex ID: W4417000507