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Cover Feature: Tetrahydroindolone‐Dihydropyrimidinone Hybrids as Promising Antibiofilm and Antibacterial Agents (ChemMedChem 23/2025)

Year: 2025

Type: article

Abstract: Novel tetrahydroindolone dihydropyrimidinone hybrid compounds exhibited significant antibiofilm activity against resistant bacterial Staphylococcus aureus and Pseudomonas aeruginosa strains, indicating molecular hybridization played crucial role to this performance. Toxicity studies using Caenorhabditis elegans model revealed no observable toxicity, even at elevated concentrations. Combination of strong antibiofilm activity with non-toxic behavior underlines the antivirulence potential, positioning the hybrid compounds as promising adjuvants in the fight against chronic bacterial infections. More details can be found in the Research Article by Karine R. Zimmer, Dennis Russowsky, and co-workers (DOI: 10.1002/cmdc.202500716).

Source: ChemMedChem

DOI: 10.1002/cmdc.70133

Authors: Vinicius Vendrusculo, Maria Paula L. S. Oliveira, Belisa A. Rodrigues, Victória S. Ramos, Júlia M. Menezes, Karine R. Zimmer, Dennis Russowsky

Institutions: Universidade Federal do Rio Grande do Sul, Instituto Federal Sul-rio-grandense, Universidade Federal de Ciências da Saúde de Porto Alegre

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4417002048

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