Glycoside Fragmentation in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry of Natural Products of Ginsenosides
Year: 2025
Type: article
Abstract: I investigated the MS/MS fragmentation of ginsenoside glycosides using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) for ginsenosides Rg1, Rh1, Rb1, and Rb3, focusing on their sodium adduct molecules [M + Na] + .The glycosidic linkage at the C-20 position cleaved more readily than those at C-3 and C-6.These glycosides fragmented on their glucosyl donor sides, exhibiting C-and Z-type fragmentation, although generally B/Y-type fragment ions are dominant in MS/MS spectra of neutral oligosaccharides.These results suggest that, due to the hydrophobic triterpene skeleton of the aglycone, sodium cations cannot effectively coordinate with the aglycone moiety.
Source: Mass Spectrometry
Author: Tohru Yamagaki
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4417010641