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Solubility, thermodynamics, and preferential solvation of 3-Nitrobenzaldehyde in Binary Ethanol/Ethyl Acetate and 1-Propanol/Ethyl acetate solvent mixtures

Year: 2025

Type: article

Abstract: • 3-NBA solubility was measured in EtOH, 1-PrOH, EA, and their mixtures from 278.15 to 303.15 K. • Four models accurately predicted solubility with deviations under 2.45 %. • Dissolution was found to be endothermic and entropy-driven. • IKBI analysis showed stronger 3-NBA solvation by EA, especially in EtOH mixtures. • Results enhance understanding of solvation and aid pharmaceutical formulation. This study examines the solubility and thermodynamic behavior of 3-nitrobenzaldehyde (3-NBA) in ethanol (EtOH), 1-propanol (1-PrOH), ethyl acetate (EA), and two binary solvent mixtures (EtOH + EA, 1-PrOH + EA). Solubility was measured using a gravimetric method and analyzed with four co-solvency models at temperatures ranging from 278.15 to 303.15 K, all showing strong predictive accuracy. Results revealed a non-monotonic solubility trend and indicated that 3-NBA dissolution is endothermic and spontaneous until the saturation point is reached. The thermodynamic properties of the mixtures were calculated using van't Hoff and Gibbs equations. Preferential solvation behavior in mixed solvents was evaluated using the IKBI method, showing a stronger affinity of 3-NBA for EA, especially in EtOH-based mixtures. Solubility, Solvent effect, Gibbs energy of transfer of 3-NBA and preferential solvation parameters ( δ x 1 , 3 ) in alcohol (1) + EAC (2) solvent mixtures

Source: Chemical Thermodynamics and Thermal Analysis

DOI: 10.1016/j.ctta.2025.100250

Authors: Adel Noubigh, Hammadi Khmissi, Amani A.S. Abdelaziz

Institutions: Northern Border University, Imam Abdulrahman Bin Faisal University

Language: English

Topic: Crystallization and Solubility Studies

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,350

Funder: Northern Border University