A decreased proportion of naïve MAIT cells is associated with the incomplete immune reconstitution in antiretroviral therapy-treated HIV-1 patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: cell subsets. Further characteristic analysis of MAIT cells via the transcriptome revealed decreased expression of cytotoxicity-related genes in INRs, while displaying increased expression of genes involved in TGF-β receptor signaling. In summary, by conducting a comparative analysis, this study revealed a correlation between the decreased proportion of naïve MAIT cells and impaired immune reconstitution in INRs. This finding highlights a particular cell subset that may play a pivotal role in the incomplete immune reconstitution, and suggests a plausible cellular target for the modulation of INRs.
Source: Virologica Sinica
Authors: Jie Jia, Hong-Yi Zheng, Yu Zhao, Kai-Cheng Gao, Deshenyue Kong, Danfeng Lu, Ji-Qun Yang, Jun-Hong Mao, Xiuwen Wang, Kun-Hua Wang, Bin Su, Jian-Hua Wang, Yong-Tang Zheng, Yi-Qun Kuang
Institutions: Kunming Medical University, First Affiliated Hospital of Kunming Medical University, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Third People's Hospital, Capital Medical University, Beijing YouAn Hospital, Yunnan University, Guangzhou Institutes of Biomedicine and Health
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $1,500
OpenAlex ID: W4417014379