Work

Corneal perforation in the setting of NK/T-cell lymphoma-associated hemophagocytic lymphohistiocytosis

Year: 2025

Type: article

Abstract: Background: . While ocular manifestations are recognized in HLH, corneal perforation has not been well-described in published reports. Case presentation: We report a case of a 26-year-old male who developed a spontaneous corneal perforation in the setting of NK/T-cell lymphoma-associated HLH. The patient was transferred to our hospital with a progressively enlarging fungating facial mass and severe bilateral eyelid edema, as well as fevers, sepsis, pancytopenia and transaminitis. Biopsy of the facial mass was consistent with extranodal natural killer/T-cell lymphoma (ENKTL), and the patient was diagnosed with HLH presumed secondary to his malignancy. Ophthalmic examination revealed a corneal perforation of his left eye. Management and outcome: The patient was taken to the operating room for repair of the perforation with a corneal patch graft. Postoperative management included topical corticosteroids and antibiotics. After surgery, the patient's left eye visual acuity was 20/100. Three months later, his visual acuity was 20/30 and the corneal patch graft appeared well-healed. Conclusion: This case highlights the potential for HLH to cause corneal perforation as a severe ocular complication. Prompt diagnosis and multidisciplinary management are crucial for optimizing outcomes in such complex cases.

Source: American Journal of Ophthalmology Case Reports

DOI: 10.1016/j.ajoc.2025.102487

Authors: John R. Mark, Jeffrey H. Ma

Institution: University of California, Davis

Language: English

Topic: Autoimmune and Inflammatory Disorders Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,590