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Toxic Epidermal Necrolysis Induced by First-Line Helicobacter pylori Eradication Therapy: A Case Report

Year: 2025

Type: article

Abstract: Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN) are rare, life-threatening adverse drug reactions. Here, we report a fatal case of TEN in an 80-year-old patient who developed diffuse bullous eruptions and multiorgan failure following first-line Helicobacter pylori eradication therapy with a proton pump inhibitor, amoxicillin, and clarithromycin. Initial symptoms appeared four days posttreatment. Despite intensive care, including corticosteroids and supportive treatment, the patient died of sepsis and progressive organ failure. This case highlights the need for early detection of severe cutaneous adverse reactions, particularly in elderly patients receiving H. pylori eradication therapy.

Source: The Korean Journal of Helicobacter and Upper Gastrointestinal Research

DOI: 10.7704/kjhugr.2025.0051

Authors: Young Woo Chae, Seung In Seo, Woon Geon Shin

Institutions: Hallym University, Kangdong Sacred Heart Hospital

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4417015354