Work

A novel method for the mechanochemical synthesis of unsymmetrical disulfides using phosphorodithioic acid derivatives

Year: 2025

Type: article

Abstract: In this study, we report the efficient synthesis of unsymmetrical disulfides using a mechanochemical ball-milling approach. This research successfully yielded alkyl-alkyl, alkyl-aryl, and aryl-aryl unsymmetrical disulfides without any detectable formation of symmetrical products. Additionally, we eliminated the use of solvent in the reaction mixture and replaced triethylamine with the more environmentally friendly cesium carbonate as a base. These results represent a significant advancement in the modern synthesis of disulfides, which have applications in pharmacology.

Source: Scientific Reports

DOI: 10.1038/s41598-025-29563-5

Authors: Mikołaj Walter, Agata Grobelna, Janusz Rachoń, Dariusz Witt, Sebastian Demkowicz

Institution: Gdańsk University of Technology

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,690

Funders: Narodowe Centrum Nauki, Politechnika Gdańska