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PH20-modified exosomes loaded curcumin inhibit desmoplastic breast cancer by breaking extracellular matrix barrier and normalizing cancer-associated fibroblasts

Year: 2025

Type: article

Abstract: T cells infiltration, contributed to effective cytotoxic inhibition on cancer cells. This green synthesized biocompatible nanoplatform offers a promising dual therapeutic strategy for remodeling desmoplastic TME and inhibiting tumor progression with effective drug delivery for improved TNBC therapeutic outcomes.

Source: Materials Today Bio

DOI: 10.1016/j.mtbio.2025.102635

Authors: Xiaoxia Xue, Xiaoyu Li, Meng Tian, Liuchunyang Yu, JinXiu Qian, Xiuyun Bai, Jue Yang, Rongjun Deng, Qiqiong Liu, Ying Xing, Yuxing Yao, Cheng Lu, Aiping Lyu, Yuanyan Liu

Institutions: Beijing University of Chinese Medicine, Shanxi University of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Hong Kong Baptist University

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,400

Funders: Hong Kong Baptist University, Beijing University of Chinese Medicine, National Major Science and Technology Projects of China

Awards: G1056828475, G4064551675, G4895420019

OpenAlex ID: W4417026747

FWCI: 1.298

Cites: 56

Cited by: 5

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