A randomised clinical trial of a digital self-management package for people with interstitial lung disease: the REBUILD-SM protocol
Year: 2025
Type: article
Abstract: BACKGROUND: Interstitial lung disease (ILD) has a profound impact upon health-related quality of life (HRQoL) and mortality. Patients with ILD have identified their desire for tools to improve self-management. This study compares the clinical efficacy and cost-effectiveness of delivering an ILD-specific self-management package through a mobile health smartphone application (the REBUILD app), with standard care. It also evaluates the barriers and facilitators to adoption of the intervention in clinical practice. METHODS: This is a prospective, multicentre, randomised control trial (RCT) with embedded economic and implementation evaluations, with recruitment via ILD clinics at four Australian tertiary hospitals. Participants are allocated 1:1 to intervention and control groups, with randomisation stratified by disease severity, diagnosis, and site. The intervention group receives the self-management package and four phone health coaching sessions over 12 weeks. The control group receives standard care and four phone calls to control for attention. Outcomes will be measured at 12, 26 and 52 weeks. The primary outcome is change in HRQoL at 12 weeks, measured by the King's Brief Interstitial Lung Disease questionnaire. DISCUSSION: Enhanced self-management has been associated with better HRQoL in several chronic respiratory conditions, however its effect in people with ILD is not known. This is the first multicentre RCT to evaluate the effect of a digital self-management intervention delivered through a smartphone app in people with ILD. If successful, this intervention has the potential to enhance access to self-management support for people with ILD. TRIAL REGISTRATION: This project was prospectively registered with the Clinical Trial Registry (NCT06122233|| https://www. CLINICALTRIALS: gov/ /{08/11/2023}}.
Source: Respiratory Research
Authors: Carly Barton, Mariana Hoffman, Narelle S. Cox, Laura M. Glenn, Joanna Y. T. Lee, Ingrid Cox, Nicole S. L. Goh, Lauren K. Troy, John Mackintosh, Daniel C. Chambers, Ian N. Glaspole, Val Gebski, Anthony Keech, Andrew Palmer, Liliana Laranjo, Luke D. Knibbs, Yuben Moodley, Mark Brooke, Anne E. Holland, Tamera J. Corte
Institutions: The University of Sydney, Royal Prince Alfred Hospital, National Health and Medical Research Council, Institute for Breathing and Sleep, Monash University, University of Tasmania, Menzies Institute for Medical Research, The University of Melbourne, The Alfred Hospital, Alfred Health, Austin Health, The University of Queensland, Prince Charles Hospital, Sydney Local Health District, The University of Western Australia, Fiona Stanley Hospital, Institute for Respiratory Health, Lung Foundation Australia
Language: English
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,490
Funder: Medical Research Future Fund
OpenAlex ID: W4417028884