Year: 2025
Type: article
Abstract: Intravenous drug self-administration has been widely used in behavioral neuroscience to model addiction and heightened motivational states; however, the technique is notoriously difficult and its utility has been in steady decline. Here, circumventing prior issues, we established a procedure for intranasal drug self-administration in head-restrained male mice. This procedure does not require surgical expertise or indwelling implants, drives robust schedule- and dose-dependent responding, and results in high blood cocaine concentrations. In addition to improved ease of use and face validity for modeling cocaine use disorder, this work provides an example of volitional nasal drug insufflation by a non-human animal, a behavior canonically thought to be unique to humans across compounds.
Source: Nature Communications
Authors: Kirsty R. Erickson, Yizhen Quan, Zahra Z. Farahbakhsh, Hannah E. Branthwaite, Keaton Song, Justin D. Kim, Janice J. Lee, Katherine N. Gibson-Corley, Eyal Y. Kimchi, Cody A. Siciliano
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,990
Funders: U.S. Department of Health and Human Services, Brain Research Foundation, W. M. Keck Foundation, Whitehall Foundation, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, National Cancer Institute, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1002678292, G1367077604, G2025152701, G2132909855, Estrogen receptor regulation of cocaine effects on dopamine terminals, G2750307456, G2838899455, G2873799643, G446292400, G5589928691, Role of the kappa opioid receptor system in learning and substance use disorders, Vanderbilt AUD Research and Education Center (VAREC), G6399140587, G7145285075, G7150749057, Defining the role of cortical circuit dynamics in learning and addiction, Mesocortical neuromodulation in punishment-resistant alcohol drinking, G725763919, G7308795399, G7484429666, G7773164252, G8045842393, G815135751, G8240749110, G8596230384, G9000037168, G9000064184, G9000089795, 8/8: INIA Stress and Chronic Alcohol Interactions: Cross-species plasticity signatures of alcohol and stress
OpenAlex ID: W4417032177