Year: 2025
Type: article
Abstract: Mucosal barrier sites are specialised interfaces that constantly defend against challenges, from tissue damage to infections. When considering these sites, we typically think of the lungs, gut, mouth or skin. However, a site often overlooked is the female reproductive tract (FRT), an equally dynamic mucosal site uniquely tasked with both immune defence and sustaining new life. The FRT undergoes dramatic tissue remodelling and can return to a homeostatic state without scarring - an ability shared only with the oral mucosa and foetal skin. Given the interconnected nature of mucosal systems, disruption of intestinal homeostasis by enteric or systemic infection has broad impacts on systemic immunity, prompting us to consider how such disturbances could impact the FRT.
Source: PLoS Pathogens
Institutions: University of Manchester, University of Edinburgh
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,043
Awards: How do CNS border-derived B-cells shape brain immunity and behaviour during chronic infections?, Investigating mucin-immune interactions in the female reproductive tract during helminth infection, Investigating mucin-immune interactions in the female reproductive tract during helminth infection, G7314759690
OpenAlex ID: W4417035407