Work

Fabrication of antibacterial carbonate apatite bone cement starting from vaterite, monetite and disodium hydrogenphosphate with gentamicin sulfate

Year: 2025

Type: article

Abstract: The present article describes the fabrication of a bioresorbable, antibacterial bone cement comprising carbonate apatite (CO3Ap) and gentamicin sulfate (GNT).We focused on a fast-setting CO3Ap cement using vaterite and monetite as raw powders and Na2HPO4 as a mixing solution, to which we added GNT.The initial setting time, physical properties, drug release property, antibacterial property, and in vivo bioresorbability and biocompatibility of the CO3Ap cements were evaluated.The addition of GNT decreased the initial setting time without affecting the other physical properties of the set cements.Moreover, the GNT-loaded CO3Ap cements demonstrated potential for drug sustained-release and prevented the growth of Escherichia coli.In vivo studies, the cement formed osteoconductive connections with the bone-like tissues in rat tibia; however, delayed bioresorption was observed.Based on these results, we conclude that GNT-loaded CO3Ap cements that reduce the risk of surgical site infection are potential candidates for bioabsorbable bone cement.

Source: Dental Materials Journal

DOI: 10.4012/dmj.2025-143