Neuritin: a multifaceted neuroprotective factor with emerging applications for neurodegeneration
Year: 2025
Type: article
Abstract: Neuritin is a conserved, activity-regulated gene encoding a glycosylphosphatidylinositol-anchored protein, crucial for neural development, synaptic plasticity, and neuroprotection. Identified via activity-dependent gene screening in the rat hippocampus, neuritin promotes neurite outgrowth, dendritic arborization, and synaptic maturation with neural activity. In this review, we summarize recent findings regarding neuritin's signaling pathways, neuroprotective, neuroregenerative, and neuromodulatory properties, with a focus on its therapeutic potential to counter neurodegeneration in various conditions such as glaucoma, Alzheimer's disease, stroke, diabetic neuropathy, and neuropsychiatric disorders. Additionally, recent studies reveal roles in immunoregulation, angiogenesis, and cancer biology, highlighting neuritin as a versatile signaling molecule with broad therapeutic implications.
Source: Frontiers in Neuroscience
Authors: Kai L. Mongan, Tasneem P. Sharma
Institution: Indiana University School of Medicine
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4417037410