Work

A nonavalent BODIPY with a multivalent arrangement of α-mannosides enables lectins recognition in fluorescence-based assays

Year: 2025

Type: article

Abstract: dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and langerin, were further investigated. The approach proposed is versatile and paves the way for the development of multivalent and fluorescent glyco-BODIPY probes useful to interrogate carbohydrate-lectin interactions in different biological contexts.

Source: RSC Chemical Biology

DOI: 10.1039/d5cb00190k

Authors: Giacomo Biagiotti, Edvin Purić, Jacopo Tricomi, Janez Mravljak, Stefano Cicchi, Marco Laurati, Yvette van Kooyk, Fabrizio Chiodo, Iztok Urbančič, Marko Anderluh, Barbara Richichi

Institutions: University of Florence, University of Ljubljana, Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam, Istituto di Chimica Biomolecolare, National Research Council, Jožef Stefan Institute, Jožef Stefan International Postgraduate School

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,962

Funders: Dipartimenti di Eccellenza, European Commission, Ministero dell’Istruzione, dell’Università e della Ricerca, Javna Agencija za Raziskovalno Dejavnost RS, Università degli Studi di Firenze, European Regional Development Fund

Awards: G1115267702, G121895856, Medicinal chemistry - drug design, synthesis and evaluation, G2107432758, G3894281659, G4545074464, G4781470135, G5131656165, G5336352252, G5746855751, Experimental biophysics of complex systems and imaging in biomedicine, G658310711, G7829988467, G8011802531, G8509537321

OpenAlex ID: W4417038347

FWCI:

Cites: 40

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