Work

Advances in the use of exosomes for the diagnosis and treatment of ovarian cancer

Year: 2025

Type: article

Abstract: Ovarian cancer (OC) is the most lethal gynecologic malignancy, with insidious early symptoms and a lack of effective screening often leading to late-stage diagnosis and poor prognosis. Exosomes, extracellular vesicles carrying diverse bioactive molecules, play key roles in OC pathogenesis and progression. This review systematically outlines recent advances in exosome research, highlighting their dual potential as liquid biopsy biomarkers for early diagnosis and prognosis, and as natural drug delivery systems for targeted therapy. We also critically analyze the major challenges in clinical translation. Despite existing hurdles, exosome-based strategies hold significant promise for advancing precision medicine in OC.

Source: World Journal of Surgical Oncology

DOI: 10.1186/s12957-025-04135-z

Authors: Jiyu Chen, Qingqing Tan

Institution: Nanjing Medical University

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,990