Work

Severe Refractory Calcitriol-Mediated Hypercalcemia in Diffuse Large B-Cell Lymphoma Treated With Hemodialysis

Year: 2025

Type: article

Abstract: Hypercalcemia of malignancy is a recognized complication of diffuse large B-cell lymphoma (DLBCL) and is associated with decreased survival time and more advanced disease. We present a case of DLBCL complicated by severe refractory calcitriol-mediated hypercalcemia and renal failure that was unresponsive to conventional treatments. Treatment with glucocorticoids and concurrent antiresorptive therapy was also ineffective. Ultimately, hemodialysis was necessary to treat the patient's hypercalcemia and tenuous volume status. This case demonstrates that calcitriol-mediated hypercalcemia of malignancy in DLBCL may be unresponsive to standard hypercalcemia interventions, and it supports the utility of hemodialysis as a method of treating hypercalcemia, especially in patients with renal impairment.

Source: JCEM Case Reports

DOI: 10.1210/jcemcr/luaf274

Authors: Julius Wu, Gitanjali Reddy, Zhanna Zavgorodneva, Lisel Hope

Institution: SUNY Downstate Health Sciences University

Language: English

Topic: Parathyroid Disorders and Treatments

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $930