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Refractory ITP: revisiting definitions, diagnostics, and management paradigms

Year: 2025

Type: article

Abstract: Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disorder characterized by decreased platelet counts and a variable propensity for bleeding. Significant strides have delineated the pathophysiologic mechanisms of ITP and led to new therapeutics. Despite these advances, 5% to 30% of patients persist with low platelet counts and/or ongoing bleeding. This review summarizes the current definitions and pathophysiology of refractory ITP, revisiting diagnostic realms and management strategies for these difficult-to-treat patients.

Source: Hematology

DOI: 10.1182/hematology.2025000720

Authors: Sandhya R. Panch, Ganesh Raman, James B. Bussel

Institutions: University of Washington, Fred Hutch Cancer Center, Weill Cornell Medicine

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4417041714

FWCI: 3.269

Cites: 73

Cited by: 5

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