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Reactor and kinetic study advances for highly acidic solvolysis-mediated Friedel–Crafts reaction

Year: 2025

Type: article

Abstract: This study presents a kinetic model that simulates the consumption of 4-hydroxybenzoic acid (4-HBA), the formation of di-isopropyl benzoic acid (DIPBA) via a Friedel–Crafts alkylation reaction, and the generation of key impurities.

Source: Reaction Chemistry & Engineering

DOI: 10.1039/d5re00379b

Authors: Colin Bailey, Connor Donlan, Matthew Glace, Gabrielle Broussard, Someshwar Nagamalla, Lane B. Carasik, Thomas D. Roper

Institution: Virginia Commonwealth University

Language: English

Topic: Chemical Synthesis and Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funder: U.S. Department of Commerce

Award: G8593498043

OpenAlex ID: W4417042572

FWCI:

Cites: 38

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