Increased prevalence of postpartum haemorrhage in pregnancies resulting from oocyte donation compared with IVF or natural conception: a systematic review and meta-analysis
Year: 2025
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Oocyte donation enables an increasing number of women to conceive. However, oocyte donation pregnancies have a high risk for pregnancy complications, such as severe postpartum haemorrhage (PPH). This systematic review and meta-analysis were conducted to provide an overview of current existing knowledge on the risk of developing PPH in oocyte donation pregnancies, and its possible pathophysiology. A systematic search was conducted in PubMed and Embase databases to retrieve observational studies that compared oocyte donation pregnancies with autologous oocyte IVF/intracytoplasmic sperm injection (AO-IVF/ICSI) pregnancies and naturally conceived pregnancies, reporting on PPH as one of the outcome measures. The literature search yielded 18 eligible studies for the systematic review; of these, 17 were included in the meta-analysis. The meta-analysis showed an overall significantly higher risk of PPH in oocyte donation pregnancies compared with AO-IVF/ICSI pregnancies (OR 2.32, 95% CI 1.88-2.87) and naturally conceived pregnancies (OR 3.15, 95% CI 2.01-4.94), although heterogeneity was present. All subanalyses using different definitions of PPH, as well as sensitivity analyses for adjusted OR and low risk of bias, showed similar results. This systematic review and meta-analysis confirm and provide more robust evidence compared with previous meta-analyses, with increased risk of PPH in oocyte donation pregnancies compared with naturally conceived pregnancies and AO-IVF/ICSI pregnancies.
Source: Reproductive BioMedicine Online
Institutions: Leiden University, Leiden University Medical Center
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W4417046276
FWCI:
Cites:
Cited by:
Related to: