Targeted C3G delivery by engineered milk exosomes for effective therapy in microplastics-induced colitis
Year: 2025
Type: article
Abstract: abundance and subsequently upregulated the metabolic L-Proline level. Molecular docking identified that L-Proline binds effectively to nuclear receptor subfamily 1 group D member 1 (NR1D1) protein, inhibiting the expression of inflammatory TLR-4/COX-2 pathway. Additionally, Exo-F6 carries exhibited similar therapeutic effects, indicating that exosomes derived from raw milk possess collaborative anti-inflammatory activities. Collectively, these findings emphasize the potential of C3G@Exo-F6 for targeted treatment of chronic colitis, providing a food-derived therapeutic approach for microplastics-induced colonic inflammation.
Source: Materials Today Bio
Authors: Yuanjie Wu, Wen Chen, Xiang Ye, Xingkai Hao, Yuhao Wen, Jian Wu, Danyang Li, Lizhou Xu
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,400
Award: G7911379180
OpenAlex ID: W4417048230