Single-Neuron Recordings Research in Children: Ethical Considerations, Feasibility, Technical Aspects, and Scientific Opportunities
Year: 2025
Type: article
Abstract: BACKGROUND: Human intracranial recordings and single-neuron recordings in particular have provided much knowledge on the mechanisms of human cognition and its impairment by disease. Improvements in recording technology, experimental design, and computational analysis methods have permitted an increasingly sophisticated understanding of uniquely human brain processes, including those underlying executive function, memory, and language. Despite the routine clinical use of intracranial recordings for invasive epilepsy monitoring in the pediatric population, there remains a significant gap between the associated research conducted in adult and pediatric neuroscientific investigation. SUMMARY: Single-neuron recordings in pediatric epilepsy patients are ethical, technically feasible, and safe. These data can provide mechanistic insights into the neurophysiology of the developing human brain. KEY MESSAGES: Routine use of invasive electrophysiological monitoring via stereoelectroencephalography studies in pediatric drug-resistant epilepsy offers opportunities to extend the utility of single-neuron recordings to the pediatric population and advance our knowledge of the neuronal basis of behaviors in children.
Source: Pediatric Neurosurgery
DOI: 10.1159/000549937
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4417049249