Work

Frequency of HLA Alleles in a Cohort of 100 Romanian Late-Life Adults: An Academic Insight into Genetic Longevity

Year: 2025

Type: article

Abstract: The human leukocyte antigen (HLA) system plays a crucial role in regulating the immune response and is significant in organ transplantation, disease association studies, and population genetics. But does it influence longevity? The present study aims to explore the frequency of HLA alleles in a cohort of 100 individuals in the 65-90 age bracket from Romania, providing insights into genetic diversity and potential implications in longevity. High-resolution HLA typing was performed using next-generation sequencing (NGS) technology, allowing for precise identification of HLA alleles with a high degree of accuracy. The results reveal significant genetic diversity within the cohort, with prevalent alleles such as HLA-A*02:01:01:01, HLA-B*08:01:01:01, and DRB1*01:01:01:01 potentially influencing disease susceptibility and longevity. The study reveals the genetic diversity of HLA alleles in elderly Romanians, highlighting prevalent alleles that could be linked to longevity and disease resistance. Different results from previous research are attributed to the high-resolution analysis and small cohort size. Further studies with larger samples are needed to confirm findings and uncover their implications for healthy aging and healthcare.

Source: Current Issues in Molecular Biology

DOI: 10.3390/cimb47121018

Authors: Radu-Alexandru Truică, Adriana Tălăngescu, Ion Mărunțelu, Alexandra-Elena Constantinescu, Ileana Constantinescu

Institutions: Carol Davila University of Medicine and Pharmacy, Institutul Clinic Fundeni, Academia Oamenilor de Știință din România, Romanian Academy

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,654