Work

Antibiotic prophylaxis against electrocoagulation syndrome after esophageal endoscopic submucosal dissection: a single center retrospective study

Year: 2025

Type: article

Abstract: BACKGROUND: Endoscopic submucosal dissection (ESD) is widely used to treat superficial lesions of the esophagus. Post-ESD electrocoagulation syndrome (PEECS) is a commonly occurring adverse event, however, the efficacy of antibiotic prophylaxis in preventing PEECS remains unclear. AIMS: To evaluate the efficacy of antibiotic prophylaxis (AP) in reducing the incidence of PEECS in patients undergoing esophageal ESD. METHODS: This retrospective study included consecutive patients who underwent ESD for single esophageal lesions at The First Affiliated Hospital, School of Medicine, Zhejiang University (1/2022-12/2024). Propensity score (PS) matching was applied to compare outcomes between AP and non-AP groups. Outcomes included incidences of PEECS, fever, and chest pain, along with various laboratory parameters and the length of stay (LOS) in the hospital. RESULTS: After PS matching, 262 patients were analyzed. The incidence of PEECS was 26.7% in the AP group versus 30.5% in the non-AP group, but this was not significantly different (P = 0.494). Univariate analysis identified muscle layer injury as a potential risk factor for PEECS [OR 1.986, 95%CI 1.125-3.504, P = 0.018]. CONCLUSION: AP did not reduce PEECS incidence in patients undergoing esophageal ESD.

Source: Surgical Endoscopy

DOI: 10.1007/s00464-025-12442-5

Authors: Yi-Ru Zhao, Xue-Qun Zhang

Institutions: First Affiliated Hospital Zhejiang University, Zhejiang University

Language: English

Topic: Esophageal Cancer Research and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,390