Work

Generation of an induced pluripotent stem cell line (KCGMHi003-A) from a patient with spinocerebellar ataxia type 8 (SCA8)

Year: 2025

Type: article

Abstract: Spinocerebellar Ataxia Type 8 (SCA8) is a rare, dominantly inherited neurodegenerative disorder characterized by progressive ataxia and nystagmus, and dysarthria. SCA8 is caused by bidirectional CTG/CAG repeat expansion in the ATXN8OS and ATXN8 gene. Peripheral blood mononuclear cells obtained from a SCA8 patient were successfully transformed into induced pluripotent stem cells (iPSC) (KCGMHi003-A) using Sendai virus. Our approach provided a resource for future pathogenesis study and drug screening of SCA8.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2025.103879

Authors: Min-Yu Lan, Sheng-Jye Lim, Huai-En Lu, Meng-Han Tsai

Institutions: Kaohsiung Chang Gung Memorial Hospital, National Yang Ming Chiao Tung University, National Sun Yat-sen University, Chang Gung University

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,360