Work

A respiratory signature of disease progression in the Pompe rat

Year: 2025

Type: article

Abstract: We used a novel algorithm for breath-by-breath detection on concurrent plethysmography and diaphragm EMG recordings to identify shifts in breathing throughout the lifespan of Pompe rats. We identified a "respiratory signature" of disease progression in the Pompe rat comprising a decrease in the frequency of sniffing behaviors and increased latency from diaphragm activation to inspiratory flow during hypoxia. This signature offers new metrics to evaluate the effectiveness of potential therapies.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00305.2025

Authors: Alyssa R. Mickle, Sabhya Rana, Ethan S. Benevides, Barry J. Byrne, David D. Fuller, Erica A. Dale

Institution: University of Florida

Language: English

Topic: Neuroscience of respiration and sleep

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institutes of Health