Physical association of NHE3 and SGLT2 mediated by accessory proteins in the renal proximal tubule
Year: 2025
Type: article
Abstract: This study reveals that NHE3, SGLT2, and their accessory proteins, PDZK1 and MAP17, assemble into a multiprotein complex in the renal proximal tubule. The merged NHE3-SGLT2 signals show distinct intensity in females, suggesting potential sex-specific differences in complex composition or organization. Acute empagliflozin infusion modifies the colocalization patterns of NHE3 with SGLT2 and MAP17 without disrupting complex integrity, supporting a model in which SGLT2 inhibitors regulate NHE3 through conformational rearrangements within this native complex.
Institutions: Universidade de São Paulo, Universidade Estadual do Ceará
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Awards: Pleiotropic effects of antidiabetic agents and their pharmacological targets: renoprotective mechanisms beyond glycemic control, G2339903495, Mechanisms underlying the inhibitory effect of gliflozins on NHE3 activity in the renal proximal tubule, G4210523201, Molecular bases of renal tubular function and dysfunction, G505225972
OpenAlex ID: W4417050754