Work

Uncoupling protein 1 in nonadipose tissue

Year: 2025

Type: article

Abstract: Our findings reveal UCP1 expression begins from E10.5, particularly in the brain, kidney, ear, eye, mammary gland, and reproductive system. During embryonic development, UCP1 expression is more prevalent in nonadipose tissues, compared to adulthood, especially in epithelial cells. Notably, UCP1-knockout mice exhibit developmental defects in retinas, suggesting UCP1 has physiological functions beyond thermogenesis. Our study highlights using Ucp1-promoter-driven tamoxifen-inducible Cre can minimize off-target effects in gene manipulation within thermogenic adipocytes compared to traditional Cre methods.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00260.2025