Cross-cultural adaptation and psychometric validation of the Spanish version of the Nasal Polyposis Quality of Life Questionnaire (NPQ)
Year: 2025
Type: article
Abstract: INTRODUCTION: To perform the cross-cultural adaptation into Spanish and the psychometric validation of the Nasal Polyposis Quality of Life Questionnaire (NPQ) for use in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). METHODS: A total of 140 adult patients diagnosed with CRSwNP were included. The original NPQ was adapted from Italian into Spanish following established international guidelines. Construct validity was assessed through exploratory factor analysis (EFA) with principal components. Internal consistency was analyzed using Cronbach's alpha coefficient. Test-retest reliability was determined by the intraclass correlation coefficient (ICC). Concurrent validity was examined using Pearson correlations with the SNOT-22 and NOSE-E questionnaires. Discriminant validity was analyzed using ROC curves. RESULTS: EFA revealed a five-factor structure explaining 67% of the total variance. The Spanish NPQ showed excellent internal consistency (Cronbach's α = 0.917) and high test-retest reliability (ICC = 0.991; 95% CI: 0.983-0.996). The standard error of measurement (SEM) was 2 points, and the minimal detectable change (MDC95) was 5 points. Strong correlations were observed with the NOSE-E (r = 0.802) and SNOT-22 (r = 0.870). The NPQ total score demonstrated high discriminative ability for severe symptoms (AUC = 0.947), with a cutoff point >41 providing 88.9% sensitivity and 93.3% specificity. CONCLUSIONS: The Spanish version of the NPQ is a valid, reliable, and clinically useful instrument for assessing symptom burden in patients with CRSwNP. Its multidimensional structure allows capturing the specific impact of this phenotype and supports its use in both clinical practice and research.
Authors: María Alharilla Montilla-Ibañez, Javier Modesto García-Fernández, María Soledad Sánchez-Torices, María Pilar Gómez-Gallego, Miguel Ángel Feliz-Fernández, Rafael Lomas-Vega
Institutions: Universidad de Jaén, Complejo Hospitalario de Jaén
Language: English
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,680
OpenAlex ID: W4417051674