Work

AI-Integrated Micro/Nanorobots for Biomedical Applications: Recent Advances in Design, Fabrication, and Functions

Year: 2025

Type: article

Abstract: The integration of artificial intelligence (AI) and micro/nanorobotics is fundamentally reshaping biosensing by enabling autonomous, adaptive, and high-resolution biological analysis. These miniaturized robotic systems fabricated using advanced techniques such as photolithography, soft lithography, nanoimprinting, 3D printing, and self-assembly can navigate complex biological environments to perform targeted sensing, diagnostics, and therapeutic delivery. AI-driven algorithms, mainly those in machine learning (ML) and deep learning (DL), act as the brains of the operation, allowing for sophisticated modeling, genuine real-time control, and complex signal interpretation. This review focuses recent advances in the design, fabrication, and functional integration of AI-enabled micro/nanorobots for biomedical sensing. Applications that demonstrate their potential range from quick point-of-care diagnostics and in vivo biosensing to next-generation organ-on-chip systems and truly personalized medicine. We also discuss key challenges in scalability, energy autonomy, data standardization, and closed-loop control. Collectively, these advancements are paving the way for intelligent, responsive, and clinically transformative biosensing systems.

Source: Biosensors

DOI: 10.3390/bios15120793

Authors: Prashant Kishor Sharma, Chia-Yuan Chen

Institution: National Cheng Kung University

Language: English

Topic: Micro and Nano Robotics

Subfield: Condensed Matter Physics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,654

Funders: National Science and Technology Council, National Science and Technology Council