Year: 2025
Type: article
Abstract: The growing concern over antibiotic resistance necessitates novel strategies to enhance antimicrobial efficacy. This study investigates the synergistic effect of fullerene C 60 on antibiotic susceptibility in Escherichia coli . In a standardized modification of the disc diffusion method, the zones of inhibition were measured on Mueller–Hinton agar with and without supplementation of fullerene C 60 after incubation for 10 and 24 h, respectively. Fullerene C 60 was noted for strengthening the antibacterial action of several antibiotics, especially to the extent of conversion of the bacteriostatic effect to bactericidal over a period. A statistically significant enhancement in the diameter of zones of inhibition was observed with tetracycline and co-trimoxazole, whereas amikacin and gentamicin evidenced only slight increases. The findings indicate that fullerene C 60 could disrupt bacterial membrane integrity or metabolic activity, thereby potentiating the antibiotics. This paves the way for introducing nanomaterials like fullerene C 60 into treatment strategies to target antibiotic resistance and bring about better therapeutic outcomes in bacterial infections.
Source: Scientific Reports
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W4417061602