Predictive potential of five genes of cuproptosis for survival in LGG
Year: 2025
Type: article
Abstract: Low-grade glioma (LGG) is a common primary tumor in the central nervous system. The function of several types of cell death has been proved in tumorigenesis of low-grade glioma (LGG). Cuproptosis , a new form of cell death, has been defined in recent years. We put forward the function between cuproptosis and LGG for the first time. According to TCGA datasets, we performed a univariate Cox regression analysis and got 5 hub risk genes related to the survival of LGG. Then, we constructed a prognostic risk mode by using LASSO method and demonstrated that risk score is independent prognostic risk factor by using univariate and multivariate Cox regression analyses . The above results were verified in CGGA datasets. Next, we compared the immune characteristics by using CIBERSORT, ssGSEA and demonstrated that 5 hub genes play an important role in tumor immunotherapy. Finally, we performed GO term and KEGG pathway analyses and found 5 hub genes are likely to change the biological functions of LGG by regulating the metabolism related components. We believe that our results will provide a new strategy for tumor treatment.
Source: Precision medication.
Authors: Xiaopeng Li, Yanpeng Xia, Tao zhou, Chunyan Zhu, Qian Zhang, Rongliang Guo, Shuanli Xin
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4417064748