Work

Chronic intermittent hypoxia increases Parkinson's disease susceptibility via PPARα-mediated lipid droplet-mitochondrial dysfunction

Year: 2025

Type: article

Abstract: This study reveals a previously unrecognized LD-mitochondrial regulatory axis underlying CIH-associated PD pathology and highlights its potential as a therapeutic target against CIH-accelerated neurodegeneration.

Source: Theranostics

DOI: 10.7150/thno.122944

Authors: Ming-Rui Zhai, Jie Pan, Zhen-Huan Wu, Yu-Ying He, Kai-Run Zhang, Long Ren, Yu-Rong Wang, Yi-Bing Li, Jun Gao, Lei Xiao, Yue-Hua Liu

Institutions: Fudan University, Shanghai Stomatological Hospital, Frontiers Center for Brain Science of the Ministry of Education

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W4417068292

FWCI: 3.816

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Cited by: 7

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