Schisandrin B Targets PXR to Enhance Bile Acid Metabolism and Alleviate ANIT-Induced Cholestatic Liver Injury via Dual Pathways
Year: 2025
Type: article
Abstract: blocked these effects of Sin B. Mechanistic investigation revealed that Sin B is directly binds to PXR at residues S106, G144, and W299, inducing conformational changes in the ligand-binding domain (LBD) was verified through target fishing, molecular dynamics (MD) simulations, drug affinity responsive target stability assay, isothermal titration calorimetry and surface plasmon resonance. Our findings provide structural and functional insights into the dual-pathway mechanism of Sin B and support its therapeutic potential for CLI.
DOI: 10.7150/ijbs.121475
Authors: Ying Zhang, Huan Lan, Xuechun Yu, Lin Zhuo, Bixin Zhao, Fang Liu, Lin An, Fan Zhang, Zhongqiu Liu, Caiyan Wang
Institution: Guangzhou University of Chinese Medicine
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W4417068351