Work

Discovery of Novel Bifunctional Agents as Potent TRK Inhibitors and Degraders against xDFG Mutation Resistance

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c02491

Authors: Jian Song, Jingjie Zhu, Wenjian Zhu, Jinwei Feng, Jiarong Fan, Yi Mei, Qiren Shi, Yuzhuo Yang, Zhijie Feng, Peng Wang, Tianduanyi Wang, Shengtao Xu, Jinyi Xu, Huajian Zhu

Institutions: China Pharmaceutical University, University of Helsinki, Institute for Molecular Medicine Finland

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation, National College Students Innovation and Entrepreneurship Training Program

Awards: G1171804357, G4579652716, G4636632374, G6861530313, G853280700

OpenAlex ID: W4417069024

FWCI:

Cites: 39

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