Preoperative Albumin-to-Fibrinogen Ratio as an Outcome Predictor in Triple-Negative Breast Cancer
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To elucidate the prognostic value of the albumin-to-fibrinogen ratio (AFR) in patients with triple-negative breast cancer (TNBC). STUDY DESIGN: An observational study. Place and Duration of the Study: Department of Medical Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China, from January 2010 to October 2022. METHODOLOGY: A total of 195 patients diagnosed with TNBC were recruited and followed up till October 2022. The optimal cut-off value of AFR was assessed via receiver operating characteristic curve analysis, after which patients were categorised into low and high AFR groups accordingly. The relevance between TNBC and clinicopathological parameters were evaluated using χ2 and Fisher's exact tests. Survival time was analysed by using the Kaplan-Meier method and log-rank tests. Prognostic factors were identified via Cox regression model analysis. Nomograms were constructed, and calibration curve analysis (CCA) and decision curve analysis (DCA) were applied to evaluate their predictive clinical application. RESULTS: The optimal cut-off value of AFR was 15. The median survival time of patients with high-AFR values was higher than those with low-AFR values (DFS: 36.54 vs. 33.19 months, p = 0.004; OS: 56.45 vs. 53.29 months, p = 0.003). According to the Cox regression model, AFR was a significant predictor of disease-free survival [DFS; hazard ratio (HR): 0.595, 95% CI: 0.377-0.940, p = 0.026] and overall survival (OS; HR: 0.385, 95% CI: 0.221-0.670, p = 0.001). CCA and DCA indicated that AFR-based nomograms had good predictive clinical utility within the threshold probability range for different survival rates. CONCLUSION: AFR is easy and inexpensive to conduct and has the potential to serve as a predictive factor for preoperative evaluation in clinical practice. KEY WORDS: Albumin-to-fibrinogen ratio, Triple-negative breast cancer, Albumin, Fibrinogen, Treatment.
Authors: Shuo Wu, Weijie Li
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4417070675
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