Work

Palladium‐Catalyzed Aryloxycarbonylayion of Aryl Bromides with Phenols Using Inositol Hexaformate as an Efficient CO Source

Year: 2025

Type: article

Abstract: Carbonylation represents a straightforward and powerful strategy for installing carbonyl groups into organic molecules. However, the widespread adoption of carbon monoxide gas in laboratories is hampered by its toxicity, flammability, and smell‐less properties. To address these challenges, we developed a new carbon monoxide surrogate, inositol hexaformate (HFI), and demonstrated its utility in the palladium‐catalyzed aryloxycarbonylation of aryl bromides with phenols. Notably, HFI efficiently releases six equivalents of carbon monoxide, showing a significant improvement in efficiency over commonly used formate surrogates. This work provides a practical and robust method for conducting carbonylation reactions, which is expected to broaden the accessibility of this important transformation in synthetic chemistry.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70261

Authors: Zhen‐Wei Liu, Yong‐Wang Huo, Xiao‐Feng Wu

Institutions: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Leibniz Institute for Catalysis, Dalian National Laboratory for Clean Energy

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,650

Funder: Dalian Institute of Chemical Physics