Integrin-specific binding macrocyclic RGD peptides functionalized with dinitrophenol as multivalent antibody-recruiting molecules to enhance cytotoxicity in cancer immunotherapy
Year: 2025
Type: article
Abstract: We developed a novel multivalent antibody-recruiting molecule (D3) functionalized with a macrocyclic RGD peptide with high selectivity for α v β 3 integrins and an excellent cytotoxic effect in tumor cells.
Source: RSC Medicinal Chemistry
DOI: 10.1039/d5md00879d
Authors: Xiaozhong Cheng, Chenrui Hu, Wanru Gao, Yajun Chen, Wei Wang, Guilan Zhu, Zhimeng Wu
Institutions: Hefei Normal University, Jiangnan University
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G6008430101
OpenAlex ID: W4417072140