Quality of life in patients with gallbladder polyps: a multicentre prospective cohort study
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Patients with gallbladder polyps (GPs) are frequently subject to surveillance or cholecystectomy due to a risk of malignancy. As most GPs prove to be benign, potential overtreatment may impact quality of life (QoL). This study aimed to evaluate QoL in patients with GPs, compare it to the general population, and identify factors associated with QoL. METHODS: Patients diagnosed with GPs were included from 26 Dutch centres from 2018 to 2020, and followed until 2024. QoL was assessed at multiple time points using generic (EQ-5D) and disease-specific (GIQLI) instruments. Demographics, imaging, and surgical data were analysed. RESULTS: Among 207 patients, 42 (20.3 %) underwent cholecystectomy; neoplastic polyps were found in 3 (1.4 %). Overall, baseline EQ-5D scores were similar to the general population (0.85 vs 0.87; p = 0.20), while GIQLI scores were lower (116.1 vs 122.6; p < 0.001). Anxiety was reported by 39 % and was the strongest predictor of reduced QoL (EQ-5D: β = -0.095; GIQLI: β = -15.49; p < 0.001). QoL was not associated with GP characteristics. CONCLUSION: GPs are associated with reduced QoL, driven predominantly by anxiety. Structured counselling on low malignancy risk and less intensive surveillance may alleviate anxiety and reduce overtreatment.
Source: HPB
Authors: Sander R.W.J. Martens, Mike van Dooren, Jarmila van der Bilt, Marieke T. de Boer, Djamila Boerma, Philip Bos, Andries E. Braat, Steve M.M. de Castro, Bartholomeus J.G.A. Corten, Freek Daams, Joris I. Erdmann, Floris Ferenschild, Ansje S. Fortuin, Anna van Geloven, Erik van der Hoeven, Rutger Klicks, Flip M. Kruyt, Barbara S. Langenhoff, Mike S.L. Liem, Philip V.M. Linsen, Misha Luyer, Vincent B. Nieuwenhuijs, Pim Olthof, Peter W. Plaisier, Charles van Rossem, Ruud Schrauwen, Jennifer Schreinemakers, Gian P. Serafino, Ernst J. Spillenaar Bilgen, Koen Talsma, Merel M. Tielemans, Charlotte J. Tutein Nolthenius, Elise A.J. de Savornin Lohman, Philip R. de Reuver
Institutions: Radboud University Nijmegen, Radboud University Medical Center, Flevoziekenhuis, University Medical Center Groningen, St. Antonius Ziekenhuis, Ziekenhuis Gelderse Vallei, Leiden University Medical Center, OLVG, Amsterdam University Medical Centers, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, University of Amsterdam, Tergooi, Elisabeth-TweeSteden Ziekenhuis, Medisch Spectrum Twente, Albert Schweitzer Ziekenhuis, Jeroen Bosch Ziekenhuis, Catharina Ziekenhuis, Isala, Reinier de Graaf Hospital, Maasstad Ziekenhuis, Ziekenhuis Bernhoven, Amphia Ziekenhuis, Rijnstate Hospital, Deventer Ziekenhuis, Bravis Ziekenhuis
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,100
OpenAlex ID: W4417072500