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Squamous cell carcinoma of the sigmoid colon: a rare case report

Year: 2025

Type: article

Abstract: Squamous cell carcinoma (SCC) of the colorectum is rare malignancy. It constitutes only 0.1-0.25 per 1000 cases of colorectal carcinoma. Here, we report a rare case of primary SCC of the sigmoid colon in a 40-year-old female from Western Uttar Pradesh, India. She presented with acute intestinal obstruction and a history of altered bowel habits and decreased appetite. Surgical resection revealed a constricted tumor in the sigmoid colon. Histopathological analysis confirmed the diagnosis of SCC with no lymph node involvement (0/32). The patient received four cycles of adjuvant chemotherapy (FOLFOX regimen) and has remained disease-free during a 3-year follow-up. Given its rarity, there is no established treatment protocol for colorectal SCC. Surgical resection remains the mainstay of treatment, with uncertain benefits from chemotherapy or radiotherapy. Early diagnosis and long-term follow-up are crucial for favorable outcomes in such uncommon presentations.

Source: Journal of Surgical Case Reports

DOI: 10.1093/jscr/rjaf607

Authors: Sadiq Husain, Mohammad Aslam

Institution: Aligarh Muslim University

Language: English

Topic: Colorectal and Anal Carcinomas

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,000