Work

Hydrophobic ciprofloxacin derivatives as dual-functional photoinitiators for photocurable polylactide scaffolds in treatment of infected bone defects

Year: 2025

Type: article

Abstract: 10% for Cpf-Allyl), approaching the efficiency of the commercial photoinitiator Bis-b. All photosensitive resins achieved high degrees of conversion (DC ≥ 60%) for the 1PP-method. In contrast, Cpf-VBC-based 2PP scaffolds showed a significantly lower DC (29 ± 4%) compared to both Cpf-Allyl-based and Bis-b-based scaffolds (∼58%). However, the use of Cpf-VBC resulted in increased surface hydrophilicity of the scaffolds, as evidenced by lower water contact angles (62 ± 2°) and a higher polar component of surface energy. All fabricated scaffolds promoted the proliferation of mesenchymal stromal cells and their efficient osteogenic differentiation supported by scaffold mineralization. The scaffolds exhibited topographical and mechanical properties suitable for bone tissue engineering, with a Young's modulus (262-377 MPa) in the range of human cancellous bone.

Source: Biomaterials Science

DOI: 10.1039/d5bm01345c