A Rare Case of Brain Manifestation of Manganese Toxicity and Its Management: A Case Report and Literature Review
Year: 2025
Type: article
Study design: Case Report
Abstract: Manganese (Mn) toxicity is a rare but perplexing condition, often difficult to diagnose due to its unusual clinical presentation. Mn toxicity's neurological symptoms can be nonspecific, making early diagnosis crucial. The unique association between chronic liver disease and Mn toxicity highlights the need for increased clinical awareness and further research. We present a case of a five-year-old Asian male child with chronic liver disease who presented with neurological symptoms due to brain Mn deposition and its management. Notably, Mn exhibits a propensity for preferential accumulation in the basal ganglia, specifically targeting dopamine-producing (DAergic) neurons. The child's response to interventions, including a reduction in Mn deposition in the brain using chelating therapy, underscores the significance of early recognition and comprehensive management in addressing this condition. This case report delves into an exceptional instance of Mn toxicity, emphasizing the significance of early recognition and interdisciplinary intervention.
Source: Cureus
DOI: 10.7759/cureus.98567
Authors: Maulinkumar N Patel, Aastha Arunkumar Patel, Chandan Alenahalli Narayana, Rutuja Tere, Dhruvil Vinaybhai Patel, Saniah Khan, Zenia Elavia, Mansi Singh
Institutions: The University of Texas Health Science Center at Houston, Bangalore Medical College and Research Institute, Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College, King Edward Medical University, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Bogomolets National Medical University
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4417077780