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The Impact of Transcranial Direct Current Stimulation (tDCS) on Craving and Relapse Rates in Opioid-Dependent Patients Undergoing Methadone Maintenance Therapy

Year: 2025
Type: article
Abstract: Background: Addiction is a chronic and debilitating condition associated with compulsive behaviors, cravings, and high relapse rates. Transcranial direct current stimulation (tDCS) is a neuromodulation technique for the treatment of substance use disorders by targeting brain areas involved in craving and inhibitory control. This study aimed to assess tDCS effectiveness in reducing cravings in opioid-dependent patients on methadone maintenance therapy (MMT). Methods: A total of 60 opioid-dependent participants were randomly assigned to either an active intervention group or a sham group. The intervention group received ten sessions of anodal tDCS applied to the left dorsolateral prefrontal cortex (DLPFC) and cathodal tDCS over the right DLPFC. Craving was measured using the Desire for Drug Questionnaire (DDQ) before and after the intervention. Findings: This study found no statistically significant differences in craving scores between the intervention and sham groups. There was no statistically significant difference in craving score changes between the two groups before and after the intervention. Conclusion: The findings of this study suggest that the specific tDCS protocol used, targeting the left DLPFC with anodal stimulation and the right DLPFC with cathodal stimulation, did not significantly reduce craving in opioid-dependent patients undergoing MMT. The study highlights the need for further research to optimize tDCS protocols and explore alternative brain targets for the treatment of substance craving and relapse prevention.
DOI: 10.34172/ahj.1620
Authors: Masoumeh Khoshkbarchi, Mazyar Fathi, Ali Talaei, Farzad Akbarzadeh, Saeed Akhlaghi, Alireza Ebrahimi
Language: English
Subfield: Neurology
Open Access status: diamond
OpenAlex ID: W4417079975
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