Staphylococcal enterotoxin C2 rescued simulated microgravity-induced bone loss and the trans-differentiation of BMSCs into adipocytes
Year: 2025
Type: article
Abstract: Exposure to microgravity decreases bone volume and increases marrow fat, partly due to impaired BMSC osteogenesis and enhanced adipogenesis. Staphylococcal enterotoxin C2 (SEC2) can influence BMSC differentiation, potentially promoting osteogenesis. This study investigated SEC2's effects on bone loss and marrow fat in hindlimb suspension (HLS) mice and BMSC differentiation under simulated microgravity. Results showed SEC2 alleviated bone deterioration and reduced marrow adiposity, promoting osteogenic over adipogenic differentiation by activating ERK/β-catenin signaling pathways. SEC2 increased ERK phosphorylation and β-catenin nuclear translocation, with effects diminished upon β-catenin knockdown. These findings reveal a novel mechanism by which SEC2 modulates BMSC fate under microgravity, highlighting its potential as a therapeutic agent for preventing bone loss and marrow adiposity in microgravity conditions.
Source: npj Microgravity
Authors: Nan Hou, Zhengmeng Yang, Haixing Wang, Xuan Lu, Shanshan Bai, Yaofeng Wang, Sien Lin, Micky D. Tortorella, Lu Feng, Gang Li
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,690
Awards: Effect of sesamin on promoting osteoprotic fracture healing, Functionalization of Wnt5a biomimetic peptide on biomaterials for enhanced bone regeneration and implant osseointegration, G3210027332, Mechanistic studies of tibial cortex transverse transport (TTT) surgery in improving diabetic foot ulcers healing outcomes, G4685367558, G7210440535, G7413394314
OpenAlex ID: W4417088368