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Rapid‐Onset Drug‐Induced Liver Injury Following Amoxicillin‐Clavulanate: A Case Report

Year: 2025

Type: article

Abstract: Drug-Induced Liver Injury (DILI) is a rare but potentially serious adverse effect of many commonly used medications. DILI is a diagnosis of exclusion and requires a high index of suspicion. Amoxicillin-Clavulanate (A-C) is a widely prescribed antibiotic known to be one of the leading causes of idiosyncratic DILI. Though well documented in Western countries, cases of DILI are less frequently reported in our region. The usual onset of DILI varies from a few days to 8 weeks after initiation of medication. Here, we report a case of an atypically rapid onset of amoxicillin-clavulanate induced liver injury in a 32-year-old female following just two doses.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.71655

Authors: Shuvam Khadka, Abinash Dev, Pramodman Singh Yadav, Sujan Acharya, Amisha Karki, Leeza Shah

Institutions: B.P. Koirala Institute of Health Sciences, University of New Mexico, Chitwan Medical College

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820