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Prognostic Factors Affecting Iodine-131 Treatment Efficacy in Patients With Differentiated Thyroid Carcinoma: A Risk-Stratified Analysis

Year: 2025

Type: article

Abstract: To analyze factors influencing iodine-131 (I-131) treatment efficacy in differentiated thyroid carcinoma (DTC). This retrospective study classified 299 patients with DTC into medium–low-risk and high-risk groups, assessing clinical data (preoperative stimulated thyroglobulin [ps-Tg], urinary iodine, gender, T stage, diet). Patients followed normal or iodine-restricted diets. Statistical analyses included t-tests, chi-squared tests and logistic regression. Medium–low risk and higher ps-Tg levels and urinary iodine concentrations correlated with less favorable outcomes (p < 0.001). High-risk patients showed significant differences in gender, T stage and ps-Tg level (p < 0.001). Multivariate analysis identified risk level, T stage and ps-Tg level as key prognostic factors (p < 0.001), with urinary iodine concentration having a minor effect (p = 0.003). Risk stratification, T stage and ps-Tg level were the primary prognostic determinants. Dietary interventions showed different effects in different risk-stratified patients, requiring individualized consideration. These findings emphasize the importance of comprehensive assessment in DTC management.

Source: Nutrition and Cancer

DOI: 10.1080/01635581.2025.2596905

Authors: Jinhao Li, Huixia Geng, Junbo Nan, Fangfang Mao, Luoping Zhai, Wanchun Zhang

Institutions: Shanxi Medical University, Shanxi Academy of Medical Sciences, First Hospital of Shanxi Medical University

Language: English

Topic: Thyroid Cancer Diagnosis and Treatment

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: ShanXi Science and Technology Department