Work

Behavioral Changes and Refractory Hypertension as the First Manifestations of Anaplastic Astrocytoma: A Case Report

Year: 2025

Type: article

Abstract: High-grade brain tumors are uncommon malignancies with poor survival prospects. Their early manifestations can be vague, often resulting in diagnostic delays. Here, we report a case of a 66-year-old woman who exhibited only subtle personality changes and an episode of severe, treatment-resistant hypertension as initial signs of a malignant neoplasm in the brain. These findings prompted neuroimaging, which revealed a large tumor in the right temporal lobe. A biopsy confirmed an anaplastic astrocytoma (WHO grade III). Because of its deep location, surgical removal was not feasible, and radiotherapy was initiated. However, the patient's condition rapidly worsened due to severe infection, and she died two months after diagnosis. This case underscores the need for vigilance in primary care: even mild behavioral changes or atypical symptoms such as unexplained hypertension in older adults should prompt early investigation for possible brain tumors.

Source: Cureus

DOI: 10.7759/cureus.98667

Authors: Julia K Marczuk, Wiktoria M Gembala, Adam T Potocki

Institution: Jagiellonian University

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4417102453